Sowin, Thomas : rechercher sur Z-Library

Année:

2005

Langue:

english

Fichier:

PDF, 317 KB

english, 2005

Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors

Gaoquan Li, Lisa A. Hasvold, Zhi-Fu Tao, Gary T. Wang, Stephen L. Gwaltney II, Jyoti Patel, Peter Kovar, Robert B. Credo, Zehan Chen, Haiying Zhang, Chang Park, Hing L. Sham, Thomas Sowin, Saul H. Ros

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 203 KB

english, 2006

Synthesis of 2-Substituted (±)-(2 R, 3 R, 5 R )-Tetrahydrofuran-3,5-dicarboxylic Acid Derivatives †

Wang, Gary T., Wang, Sheldon, Chen, Yuanwei, Gentles, Robert, Sowin, Thomas

Journal:

Rolf E. Swenson, Thomas J. Sowin, Henry Q. Zhang

Année:

2001

Langue:

english

Fichier:

PDF, 63 KB

english, 2001

Synthesis of Substituted Quinolines Using the Dianion Addition of N-Boc-anilines and α-Tolylsulfonyl-α,β-unsaturated Ketones.

Journal:

ChemInform

Année:

2003

Fichier:

PDF, 218 KB

2003

Amino-Substituted Heterocycles as Isosteres of trans-Cinnamides: Design and Synthesis of Heterocyclic Biaryl Sulfides as Potent Antagonists of LFA-1/ICAM-1 Binding.

Gary T. Wang, Sheldon Wang, Robert Gentles, Thomas Sowin, Sandra Leitza, Edward B. Reilly, Thomas W. von Geldern

Journal:

ChemInform

Année:

2005

Fichier:

PDF, 17 KB

2005

Novel indication for cancer therapy: Chk1 inhibition sensitizes tumor cells to antimitotics

Zhan Xiao, John Xue, Dimitri Semizarov, Thomas J. Sowin, Saul H. Rosenberg, Haiying Zhang

Journal:

International Journal of Cancer

Année:

2005

Langue:

english

Fichier:

PDF, 985 KB

english, 2005

Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics

Zehan Chen, Zhan Xiao, Wen-zhen Gu, John Xue, Mai H. Bui, Peter Kovar, Gaoquan Li, Gary Wang, Zhi-Fu Tao, Yunsong Tong, Nan-Horng Lin, Hing L. Sham, Jean Y. J. Wang, Thomas J. Sowin, Saul H. Rosenberg

Journal:

International Journal of Cancer

Année:

2006

Langue:

english

Fichier:

PDF, 1.69 MB

english, 2006

Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones as potent Chk1 inhibitors

Lisa A. Hasvold, Le Wang, Magdalena Przytulinska, Zhan Xiao, Zehan Chen, Wen-Zhen Gu, Philip J. Merta, John Xue, Peter Kovar, Haiying Zhang, Chang Park, Thomas J. Sowin, Saul H. Rosenberg, Nan-Horng L

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 150 KB

english, 2008

Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase

Gary T. Wang, Xilu Wang, Weibo Wang, Lisa A. Hasvold, Gerry Sullivan, Charles W. Hutchins, Steve O’Conner, Robert Gentiles, Thomas Sowin, Jerry Cohen, Wen-Zhen Gu, Haiying Zhang, Saul H. Rosenberg, Hi

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 327 KB

english, 2005

Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core

Gary T. Wang, Sheldon Wang, Robert Gentles, Thomas Sowin, Clarence J. Maring, Dale J. Kempf, Warren M. Kati, Vincent Stoll, Kent D. Stewart, Graeme Laver

Journal:

Irini Akritopoulou-Zanze, Daniel H. Albert, Peter F. Bousquet, George A. Cunha, Christopher M. Harris, Maria Moskey, Jurgen Dinges, Kent D. Stewart, Thomas J. Sowin

Année:

2005

Langue:

english

Fichier:

PDF, 308 KB

english, 2005

Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 281 KB

english, 2007

Synthesis and biological evaluation of 4′-(6,7-disubstituted-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors

Zhi-Fu Tao, Gaoquan Li, Yunsong Tong, Zehan Chen, Philip Merta, Peter Kovar, Haiying Zhang, Saul H. Rosenberg, Hing L. Sham, Thomas J. Sowin, Nan-Horng Lin

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 443 KB

english, 2007

Discovery of 4′-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-benzonitriles and 4′-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridine-2′-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitors

Zhi-Fu Tao, Gaoquan Li, Yunsong Tong, Kent D. Stewart, Zehan Chen, Mai-Ha Bui, Philip Merta, Chang Park, Peter Kovar, Haiying Zhang, Hing L. Sham, Saul H. Rosenberg, Thomas J. Sowin, Nan-Horng Lin

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 330 KB

english, 2007

Macrocyclic ureas as potent and selective Chk1 inhibitors: An improved synthesis, kinome profiling, structure–activity relationships, and preliminary pharmacokinetics

Zhi-Fu Tao, Zehan Chen, Mai-Ha Bui, Peter Kovar, Eric Johnson, Jennifer Bouska, Haiying Zhang, Saul Rosenberg, Thomas Sowin, Nan-Horng Lin

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 304 KB

english, 2007

Synthesis and in-vitro biological activity of macrocyclic urea Chk1 inhibitors

Gaoquan Li, Zhi-Fu Tao, Yunsong Tong, Magdalena K. Przytulinska, Peter Kovar, Philip Merta, Zehan Chen, Haiying Zhang, Thomas Sowin, Saul H. Rosenberg, Nan-Horng Lin

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 181 KB

english, 2007

Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: Chemistry, biological activities, and molecular modeling

Yunsong Tong, Kent D. Stewart, Sheela Thomas, Magdalena Przytulinska, Eric F. Johnson, Vered Klinghofer, Joel Leverson, Owen McCall, Niru B. Soni, Yan Luo, Nan-horng Lin, Thomas J. Sowin, Vincent L. G

Journal:

Zhi-Fu Tao, Thomas J. Sowin, Nan-Horng Lin

Année:

2008

Langue:

english

Fichier:

PDF, 490 KB

english, 2008

A facile synthesis of antitumoral indeno[1,2-c]pyrazole-4-one by mild oxidation with molecular oxygen

Journal:

William H. Pirkle, Athanasios Tsipouras, Thomas J. Sowin

Année:

2005

Langue:

english

Fichier:

PDF, 105 KB

english, 2005

Preparative separation of enantiomers by flash chromatography

Journal:

Journal of Chromatography A

Année:

1985

Langue:

english

Fichier:

PDF, 204 KB

english, 1985

Design, preparation and performance of a phthalide-based chiral stationary phase

William H. Pirkle, Thomas J. Sowin

Journal:

Journal of Chromatography A

Année:

1987

Langue:

english

Fichier:

PDF, 663 KB

english, 1987

Direct liquid chromatographic separation of phthalide enantiomers

William H. Pirkle, Thomas J. Sowin

Journal:

Journal of Chromatography A

Année:

1987

Langue:

english

Fichier:

PDF, 686 KB

english, 1987

Synthesis of α-amino and α-alkoxy aldehydes via oxoammonium oxidation

M. Robert Leanna, Thomas J. Sowin, Howard E. Morton

Journal:

Année:

1992

Langue:

english

Fichier:

PDF, 280 KB

english, 1992

An efficient enantioselective synthesis of the carbapenam-2-one system. An approach to (+)-thienamycin and related carbapenems

A.I. Meyers, Thomas J. Sowin, Stefan Scholz, Yasutsugu Ueda

Journal:

Année:

1987

Langue:

english

Fichier:

PDF, 215 KB

english, 1987

Solid phase synthesis of ureas of secondary amines via carbamoyl chloride

Gary T. Wang, Yuanwei Chen, Sheldon Wang, Richard Sciotti, Thomas Sowin

Journal:

Année:

1997

Langue:

english

Fichier:

PDF, 174 KB

english, 1997

A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation

Xiao, Zhan, Xue, John, Sowin, Thomas J, Rosenberg, Saul H, Zhang, Haiying

Journal:

Oncogene

Année:

2004

Langue:

english

Fichier:

PDF, 359 KB

english, 2004

1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyano- pyrazi-2-yl)ureas as Potent and Selective Inhibitors of Chk1 Kinase: Synthesis, Preliminary SAR, and Biological Activities

Wang, Gary T., Li, Gaoquan, Mantei, Robert A., Chen, Zehan, Kovar, Peter, Gu, Wendy, Xiao, Zhan, Zhang, Haiying, Sham, Hing L., Sowin, Thomas, Rosenberg, Saul H., Lin, Nan-Horng

Journal:

Kempf, Dale J., Sowin, Thomas J., Doherty, Elizabeth M., Hannick, Steven M., Codavoci, LynnMarie, Henry, Rodger F., Green, Brian E., Spanton, Stephen G., Norbeck, Daniel W.

Année:

2005

Langue:

english

Fichier:

PDF, 269 KB

english, 2005

Stereocontrolled synthesis of C2-symmetric and pseudo-C2-symmetric diamino alcohols and diols for use in HIV protease inhibitors

Journal:

Année:

1992

Langue:

english

Fichier:

PDF, 1.26 MB

english, 1992

Structure-Based Design, Synthesis, and Biological Evaluation of Potent and Selective Macrocyclic Checkpoint Kinase 1 Inhibitors

Tao, Zhi-Fu, Wang, Le, Stewart, Kent D., Chen, Zehan, Gu, Wendy, Bui, Mai-Ha, Merta, Philip, Zhang, Haiying, Kovar, Peter, Johnson, Eric, Park, Chang, Judge, Russell, Rosenberg, Saul, Sowin, Thomas, L

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 463 KB

english, 2007

Encyclopedia of Reagents for Organic Synthesis || Acetaldehyde

Année:

2001

Langue:

english

Fichier:

PDF, 65 KB

english, 2001

Design, Synthesis, and Structural Analysis of Influenza Neuraminidase Inhibitors Containing Pyrrolidine Cores

Wang, Gary T., Chen, Yuanwei, Wang, Sheldon, Gentles, Robert, Sowin, Thomas, Kati, Warren, Muchmore, Steve, Giranda, Vincent, Stewart, Kent, Sham, Hing, Kempf, Dale, Laver, W. Graeme

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 457 KB

english, 2001

Encyclopedia of Reagents for Organic Synthesis || Crotonaldehyde

Swenson, Rolf E., Sowin, Thomas J., Zhang, Henry Q.

Année:

2001

Langue:

english

Fichier:

PDF, 114 KB

english, 2001

Synthesis of Substituted Quinolines Using the Dianion Addition of N -Boc-anilines and α-Tolylsulfonyl-α,β-unsaturated Ketones

Journal:

Hochlowski, Jill E., Whittern, David N., Sowin, Thomas J.

Année:

2002

Langue:

english

Fichier:

PDF, 77 KB

english, 2002

Encoding of Combinatorial Chemistry Libraries by Fluorine-19 NMR

Journal:

Pirkle, William H., Sowin, Thomas J.

Année:

1999

Langue:

english

Fichier:

PDF, 57 KB

english, 1999

Synthesis and separation of diastereomeric imino alcohol derivatives of chiral phthalides: a method for assignment of phthalide absolute configurations

Journal:

Meyers, A. I., Lefker, Bruce A., Sowin, Thomas J., Westrum, Larry J.

Année:

1987

Langue:

english

Fichier:

PDF, 1003 KB

english, 1987

A facile synthesis of chiral bicyclic lactams utilized in the formation of chiral quaternary carbon compounds

Journal:

Sowin, Thomas J., Meyers, A. I.

Année:

1989

Langue:

english

Fichier:

PDF, 572 KB

english, 1989

Enantioselective synthesis of the 1.beta.-methylcarbapenems via cycloaddition of 3-siloxypentadiene and 4-acetoxyazetidinone

Journal:

Année:

1988

Langue:

english

Fichier:

PDF, 439 KB

english, 1988

Solid-Phase Organic Synthesis. Volume 1 Edited by Anthony W. Czarnik. John Wiley & Sons, New York. 2001. viii + 164 pp. 16 × 23.5 cm. ISBN 0-471-31484-6. $69.95.

Journal:

Wade, Warren S., Yang, Fan, Sowin, Thomas J.

Année:

2001

Langue:

english

Fichier:

PDF, 14 KB

english, 2001

Application of Base Cleavable Safety Catch Linkers to Solid Phase Library Production

Journal:

Pirkle, William H., Sowin, Thomas J., Salvadori, Piero, Rosini, Carlo

Année:

2000

Langue:

english

Fichier:

PDF, 121 KB

english, 2000

Correlation of the circular dichroic spectra of 3-arylphthalides with absolute configuration and conformation

Journal:

Année:

1988

Langue:

english

Fichier:

PDF, 536 KB

english, 1988

Reagents for High-Throughput Solid-Phase and Solution-Phase Organic Synthesis Edited by Peter Wipf. John Wiley & Sons, Chichester, West Sussex, England. 2005. xi + 380 pp. 22 × 29 cm. ISBN 0-470-86298-X. $140.00.

Journal:

Akritopoulou-Zanze, Irini, Sowin, Thomas J.

Année:

2005

Langue:

english

Fichier:

PDF, 26 KB

english, 2005

Solid-Phase Synthesis of Macrolide Analogues

Journal:

Beebe, Xenia, Wodka, Dariusz, Sowin, Thomas J.

Année:

2001

Langue:

english

Fichier:

PDF, 109 KB

english, 2001

Solid-Phase Synthesis of Benzoxazoles from 3-Nitrotyrosine

Journal: